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Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

12 Mar 2024

Abstract excerpt

Continued emergence of SARS-CoV-2 variants of concern that are capable of escaping vaccine-induced immunity highlights the urgency of developing new COVID-19 therapeutics. An essential mechanism for SARS-CoV-2 infection begins with the viral spike protein binding to the human ACE2. Consequently, inhibiting this interaction becomes a highly promising therapeutic strategy against COVID-19. Herein, we demonstrate...

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PMID: 38472181
DOI: 10.1038/s41467-024-45628-x

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