Article

Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo

2023-09-27

Abstract excerpt

The rapid evolution of SARS-CoV-2 variants highlights the need for new therapies to prevent disease spread. SARS-CoV-2, like SARS-CoV-1, uses the human cell surface protein angiotensin-converting enzyme 2 (ACE2) as its native receptor. Here, we design and characterize a mutant ACE2 that enables rapid affinity purification of a dimeric protein by altering the active site to prevent autoproteolytic digestion of a C-...

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Identifiers and source

Literature Corpus work: 27574200-5ff5-5e7f-8150-b4f4afcee1fb
DOI: 10.1101/2023.09.26.559550

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