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Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models

2020-07-21

Abstract excerpt

<h4>Summary</h4> To develop a vaccine candidate against COVID-19, we generated a Lentiviral Vector (LV), eliciting neutralizing antibodies against the Spike glycoprotein of SARS-CoV-2. Systemic vaccination by this vector in mice, in which the expression of the SARS-CoV-2 receptor hACE2 has been induced by transduction of respiratory tract cells by an adenoviral vector, conferred only partial protection, despite a...

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Identifiers and source

Literature Corpus work
7c810d8a-57db-568b-82a6-db190b639437
DOI
10.1101/2020.07.21.214049
Open publication

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Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical ModelsDOI 10.1101/2020.07.21.214049
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