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Article

Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers.

Journal of neurology - 1 Sept 2023

Bede Peter, Lulé Dorothée, Müller Hans-Peter, Tan Ee Ling, Dorst Johannes, Ludolph Albert C, Kassubek Jan

Abstract excerpt

BACKGROUND: The characterisation of presymptomatic disease-burden patterns in asymptomatic mutation carriers has a dual academic and clinical relevance. The understanding of disease propagation mechanisms is of considerable conceptual interests, and defining the optimal time of pharmacological intervention is essential for improved clinical trial outcomes. METHODS: In a prospective, multimodal neuroimaging study,...

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Identifiers

PMID: 37178170
DOI: 10.1007/s00415-023-11764-5
PMCID: PMC10421803

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