Article
A nonsense loss-of-function mutation in PCSK1 contributes to dominantly inherited human obesity.
International journal of obesity (2005) - 1 Feb 2015
Philippe J, Stijnen P, Meyre D, De Graeve F, Thuillier D, Delplanque J, Gyapay G, Sand O, Creemers J W, Froguel P, Bonnefond A
Abstract excerpt
BACKGROUND: A significant proportion of severe familial forms of obesity remain genetically elusive. Taking advantage of our unique cohort of multigenerational obese families, we aimed to assess the contribution of rare mutations in 29 common obesity-associated genes to familial obesity, and to evaluate in these families the putative presence of nine known monogenic forms of obesity. METHODS: Through...
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