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Article

Next-generation sequencing of 12 obesity genes in a Portuguese cohort of patients with overweight and obesity.

European journal of medical genetics - 1 Apr 2023

Manco Licínio, Pereira Janet, Fidalgo Teresa, Cunha Marina, Pinto-Gouveia José, Padez Cristina, Palmeira Lara

Abstract excerpt

We examined 12 monogenic obesity genes in 72 Portuguese individuals with overweight and obesity (class 1 and class 2), some of which with suspected genetic obesity, to identify known or unknown potential obesity variants. Genomic DNA was analyzed for variants in genes LEP, LEPR, MC4R, POMC, PCSK1, BDNF, NTRK2, SIM1, SH2B1, UCP3, GCG and ADCY3 through next generation sequencing (NGS). The impact of the rare...

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PMID: 36775011
DOI: 10.1016/j.ejmg.2023.104728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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