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Article

Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

Human heredity - 1 Jan 2025

Curtis David

Abstract excerpt

INTRODUCTION: A previous study of 200,000 exome-sequenced UK Biobank participants investigating the association between rare coding variants and BMI had implicated two genes, MC4R and PCSK1, at exome-wide significance. In addition, further 66 genes were significant with an uncorrected p value of <0.001. METHODS: Exome sequence data have become available for further 270,000 participants, and weighted burden...

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Source

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Identifiers

PMID: 41363690
DOI: 10.1159/000549644
PMCID: PMC12711242

Genes

ATP8B2
MC4R
PCSK1
GALNT9
PTOV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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