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Article

Identification and functional validation of rare coding variants in genes linked to monogenic obesity.

Obesity (Silver Spring, Md.) - 1 Sept 2024

Köroğlu Çiğdem, Traurig Michael, Muller Yunhua L, Day Samantha E, Piaggi Paolo, Wiedrich Kim, Vazquez Laura, Hanson Robert L, Van Hout Cristopher V, Alkelai Anna, Shuldiner Alan R, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: Rare cases of monogenic obesity, which may respond to specific therapeutics, can remain undetected in populations in which polygenic obesity is prevalent. This study examined rare DNA variation in established monogenic obesity genes within a community using whole-exome sequence data from 6803 longitudinally studied individuals. METHODS: Exome data across 15 monogenic obesity genes were analyzed for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39192769
DOI: 10.1002/oby.24101
PMCID: PMC11361714

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