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Genetic associations with dementia‐related proteinopathy: Application of item response theory

9 Mar 2024

Abstract excerpt

INTRODUCTION: Although dementia-related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete. METHODS: We applied multidimensional generalized partial credit modeling (GPCM) to test genetic associations with dementia-related proteinopathies. Data were analyzed to identify candidate single nucleotide variants for the...

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PMID: 38460116
DOI: 10.1002/alz.13741

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