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Article

Incorporating scientific knowledge into phenotype development: penalized latent class regression.

Statistics in medicine - 30 Mar 2011

Leoutsakos Jeannie-Marie S, Bandeen-Roche Karen, Garrett-Mayer Elizabeth, Zandi Peter P

Abstract excerpt

The field of psychiatric genetics is hampered by the lack of a clear taxonomy for disorders. Building on the work of Houseman and colleagues (Feature-specific penalized latent class analysis for genomic data. Harvard University Biostatistics Working Paper Series, Working Paper 22, 2005), we describe a penalized latent class regression aimed at allowing additional scientific information to influence the estimation...

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Identifiers

PMID: 21394753
DOI: 10.1002/sim.4137
PMCID: PMC3574638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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