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Article

Defining and predicting transdiagnostic categories of neurodegenerative disease.

Nature biomedical engineering - 1 Aug 2020

Cornblath Eli J, Robinson John L, Irwin David J, Lee Edward B, Lee Virginia M-Y, Trojanowski John Q, Bassett Danielle S

Abstract excerpt

The prevalence of concomitant proteinopathies and heterogeneous clinical symptoms in neurodegenerative diseases hinders the identification of individuals who might be candidates for a particular intervention. Here, by applying an unsupervised clustering algorithm to post-mortem histopathological data from 895 patients with degeneration in the central nervous system, we show that six non-overlapping disease...

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Identifiers

PMID: 32747831
DOI: 10.1038/s41551-020-0593-y
PMCID: PMC7946378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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