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Article

Improving genetic risk modeling of dementia from real-world data in underrepresented populations.

Communications biology - 25 Aug 2024

Fu Mingzhou, Valiente-Banuet Leopoldo, Wadhwa Satpal S, Pasaniuc Bogdan, Vossel Keith, Chang Timothy S

Abstract excerpt

Genetic risk modeling for dementia offers significant benefits, but studies based on real-world data, particularly for underrepresented populations, are limited. We employ an Elastic Net model for dementia risk prediction using single-nucleotide polymorphisms prioritized by functional genomic data from multiple neurodegenerative disease genome-wide association studies. We compare this model with APOE and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39183196
DOI: 10.1038/s42003-024-06742-0
PMCID: PMC11345412

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