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GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

8 Mar 2024

Abstract excerpt

Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear GRB2 protects DNA at stalled replication forks from MRE11-mediated degradation in the BRCA2 replication fork protection axis. Mechanistically, GRB2 binds and inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks....

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PMID: 38459011
DOI: 10.1038/s41467-024-46283-y

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