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Virus Filtration Development for Adeno‐Associated Virus‐Based Gene Therapy Products

1 Jan 2025

Abstract excerpt

Adeno-associated virus (AAV) vectors have become a leading platform for gene delivery. A major portion of gene therapy currently in clinical trials are AAV-based for a wide range of diseases. A commonly used method for AAV production is by mammalian or insect cell culture, with or without added viruses to introduce needed genetic elements for AAV production. There are potential risks of virus contamination from...

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PMID: 39778063
DOI: 10.1002/biot.202400636

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