Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2024

Sepulveda-Falla Diego, Vélez Jorge I, Acosta-Baena Natalia, Baena Ana, Moreno Sonia, Krasemann Susanne, Lopera Francisco, Mastronardi Claudio A, Arcos-Burgos Mauricio

Abstract excerpt

INTRODUCTION: Rate of cognitive decline (RCD) in Alzheimer's disease (AD) determines the degree of impairment for patients and of burden for caretakers. We studied the association of RCD with genetic variants in AD. METHODS: RCD was evaluated in 62 familial AD (FAD) and 53 sporadic AD (SAD) cases, and analyzed by whole-exome sequencing for association with common exonic functional variants. Findings were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Alzheimer's disease research and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cognitive Dysfunction

Share to Genomics and Rare Diseases

Share to Mutation

Share to Neurons

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 38450831
DOI: 10.1002/alz.13754
PMCID: PMC11032577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease.PMID 38450831Read ↗

A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer's Disease.Semantic proximity Read ↗

Familial Alzheimer's Disease and Recessive Modifiers.Semantic proximity Read ↗

Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal TransportSemantic proximity Read ↗

Rare Variant Aggregation in 148,508 Exomes Identifies Genes Associated with Proxy Alzheimer’s disease/DementiaSemantic proximity Read ↗

Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits.Semantic proximity Read ↗

Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia.Semantic proximity Read ↗

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.Semantic proximity Read ↗

Genetic Modifiers of Age at Onset in Carriers of the G206A Mutation in PSEN1 With Familial Alzheimer Disease Among Caribbean Hispanics.Semantic proximity Read ↗

Structural variants linked to Alzheimer’s Disease and other common age-related clinical and neuropathologic traitsSemantic proximity Read ↗

Association of genetic risk factors with cognitive decline: the PATH through life project.Semantic proximity Read ↗

APOE Genotype-Stratified Meta-Analysis of Cognitive Decline Reveals Novel Loci for Language and Global Cognitive Function in Older Adults.Semantic proximity Read ↗

African American exome sequencing identifies potential risk variants at Alzheimer disease lociSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.