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Article

Analytical Validation of a Telomerase Reverse Transcriptase (TERT) Promoter Mutation Assay.

The Journal of clinical endocrinology and metabolism - 13 Aug 2024

Iyer Priyanka C, Dadu Ramona, Barque Anna, Zanelli Cleslei, Zheng Xingyu, Jiang Huimin, Walsh P Sean, Hao Yangyang, Huang Jing, Klopper Joshua P, Kloos Richard T, Cabanillas Maria

Abstract excerpt

CONTEXT: Telomerase reverse transcriptase (TERT) promoter-mutated thyroid cancers are associated with a decreased rate of disease-free and disease-specific survival. High-quality analytical validation of a diagnostic test promotes confidence in the results that inform clinical decision-making. OBJECTIVE: This work aimed to demonstrate the analytical validation of the Afirma TERT promoter mutation assay. METHODS:...

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Share to DNA Mutational Analysis
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

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Share to Sensitivity and Specificity

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Source

Open in PubMed Open full text

Identifiers

PMID: 38441247
DOI: 10.1210/clinem/dgae134
PMCID: PMC11318993

Genes

TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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