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Article

Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy.

Endocrine-related cancer - 1 Oct 2014

Liu Rengyun, Xing Mingzhao

Abstract excerpt

Two promoter mutations, chr5:1 295 228C>T and chr5:1 295 250C>T, in the gene for telomerase reverse transcriptase (TERT) have been recently identified in thyroid cancers and shown to be important in thyroid tumor pathogenesis. The diagnostic and prognostic potentials of testing for these mutations on thyroid fine-needle aspiration biopsy (FNAB) have not been investigated. Herein, we examined the two TERT promoter...

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Topics

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Share to Biopsy, Fine-Needle
Share to DNA Mutational Analysis
Share to Early Detection of Cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Prognosis

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins B-raf

Share to Telomerase

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25121551
DOI: 10.1530/ERC-14-0359
PMCID: PMC4175020

Genes

TERT
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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