Article
Facilitation of Definitive Cancer Diagnosis With Quantitative Molecular Assays of BRAF V600E and TERT Promoter Variants in Patients With Thyroid Nodules.
JAMA network open - 3 Jul 2023
Fu Guodong, Chazen Ronald S, Monteiro Eric, Vescan Allan, Freeman Jeremy L, Witterick Ian J, MacMillan Christina
Abstract excerpt
Importance: Molecular testing of the presence of pathogenic genomic variants in a tumor without quantifying the variant allele fraction (VAF) does not differentiate the variation extent among tumors, often resulting in an inconclusive diagnosis because of interpatient variability. Objective: To examine the association between the quantification of VAFs of BRAF V600E and TERT promoter variants and a definitive...
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