Article
Arms-qPCR Improves Detection Sensitivity of Earlier Diagnosis of Papillary Thyroid Cancers With Worse Prognosis Determined by Coexisting BRAF V600E and Tert Promoter Mutations.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists - 1 Jul 2021
Yu Peng-Cheng, Tan Li-Cheng, Zhu Xiao-Li, Shi Xiao, Chernikov Roman, Semenov Arseny, Zhang Ling, Ma Ben, Wang Yu, Zhou Xiao-Yan, Ji Qing-Hai, Wei Wen-Jun, Wang Yu-Long
Abstract excerpt
OBJECTIVE: The coexistence of BRAF V600E and the telomerase reverse transcriptase (TERT) promoter mutation C228T/C250T is extensively associated with thyroid cancer prognosis. Our study aimed to establish a sensitive method for mutation detection and explore the correlation in detail. METHODS: The BRAF and TERT promoter mutation status of 250 papillary thyroid cancers was determined using amplification-refractory...
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