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Article

Advances in Detecting Low Prevalence Somatic TERT Promoter Mutations in Papillary Thyroid Carcinoma.

Frontiers in endocrinology - 1 Jan 2021

da Costa Vitor Rodrigues, Bim Larissa Valdemarin, Pacheco E Silva Luiza Dornelles Penteado, Colloza-Gama Gabriel Avelar, Bastos André Uchimura, Delcelo Rosana, Oler Gisele, Cerutti Janete Maria

Abstract excerpt

Background: Two recurrent TERT (telomerase reverse transcriptase) promoter mutations, C228T and C250T, have been reported in thyroid carcinomas and were correlated with high-risk clinicopathological features and a worse prognosis. Although far more frequent in the poorly differentiated and undifferentiated thyroid cancer, the TERT promoter mutations play a significant role on PTC recurrence and disease-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33776938
DOI: 10.3389/fendo.2021.643151
PMCID: PMC7994758

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