Article
Single-nucleotide polymorphisms of MMP2 in MMP/TIMP pathways associated with the risk of alcohol-induced osteonecrosis of the femoral head in Chinese males: A case-control study.
Medicine - 1 Dec 2016
Yu Yan, Xie Zhilan, Wang Jihan, Chen Chu, Du Shuli, Chen Peng, Li Bin, Jin Tianbo, Zhao Heping
Abstract excerpt
The proportion of alcohol-induced osteonecrosis of the femoral head (ONFH) in all ONFH patients was 30.7%, with males prevailing among the ONFH patients in mainland China (70.1%). Matrix metalloproteinase 2 (MMP2), a member of the MMP gene family, encodes the enzyme MMP2, which can promote osteoclast migration, attachment, and bone matrix degradation. In this case-control study, we aimed to investigate the...
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