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Article

The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes.

Cancer letters - 28 Apr 2024

Ye Zeng, Li Qiang, Hu Yuheng, Hu Haifeng, Xu Junfeng, Guo Muzi, Zhang Wuhu, Lou Xin, Wang Yan, Gao Heli, Jing Desheng, Fan Guixiong, Qin Yi, Zhang Yue, Chen Xuemin, Chen Jie, Xu Xiaowu, Yu Xianjun, Liu Mingyang, Ji Shunrong

Abstract excerpt

Cancer-associated fibroblasts (CAFs) play an important role in a variety of cancers. However, the role of tumor stroma in nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) is often neglected. Profiling the heterogeneity of CAFs can reveal the causes of malignant phenotypes in NF-PanNETs. Here, we found that patients with high stromal proportion had poor prognosis, especially for that with infiltrating...

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PMID: 38438098
DOI: 10.1016/j.canlet.2024.216769

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