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Article

Myofibroblastic cancer‐associated fibroblast subtype heterogeneity in pancreatic cancer

17 Jan 2024

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a fibrotic stroma that has both tumor-promoting and tumor-restraining properties. Different types of cancer-associated fibroblasts (CAFs) have been described. Here, we investigated whether CAFs within the same subtype exhibit heterogeneous functions. METHODS: We evaluated the gene and protein expression differences in two myofibroblastic CAF (myCAF) lines...

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PMID: 38233984
DOI: 10.1002/jso.27582

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