Article
The role of mutations in epigenetic regulators in myeloid malignancies.
Immunological reviews - 1 Jan 2015
Woods Brittany A, Levine Ross L
Abstract excerpt
Over the past decade, genomic studies have identified a number of novel and recurrent somatic mutations that affect epigenetic patterning in patients with myeloid malignancies, including myeloproliferative neoplasms, myelodysplastic syndrome, and acute myeloid leukemia. Many of these mutations occur in genes with established roles in the regulation and maintenance of DNA methylation and/or chromatin modifications...
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