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Article

The tumor suppressor p53 is a negative regulator of the carcinoma-associated transcription factor FOXQ1.

The Journal of biological chemistry - 1 Apr 2024

Pizzolato Giulia, Moparthi Lavanya, Pagella Pierfrancesco, Cantù Claudio, D'Arcy Pádraig, Koch Stefan

Abstract excerpt

The forkhead box family transcription factor FOXQ1 is highly induced in several types of carcinomas, where it promotes epithelial-to-mesenchymal transition and tumor metastasis. The molecular mechanisms that lead to FOXQ1 deregulation in cancer are incompletely understood. Here, we used CRISPR-Cas9-based genomic locus proteomics and promoter reporter constructs to discover transcriptional regulators of FOXQ1 and...

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Topics

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Share to Cell Line, Tumor
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

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Share to Promoter Regions, Genetic

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 38432629
DOI: 10.1016/j.jbc.2024.107126
PMCID: PMC10981115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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