Article
Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India.
Neuroscience letters - 10 Mar 2024
Sarkar Swagata, Biswas Arindam, Ansari Sabbir, Choudhury Supriyo, Banerjee Rebecca, Chatterjee Suparna, Dey Sanjit, Kumar Hrishikesh
Abstract excerpt
INTRODUCTION: Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson's disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key role of dopamine type 3 (D3) receptor polymorphism (Ser9Gly; rs6280) in LID. Its contribution to development of LID among Indian PD patients has remained relatively...
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