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Article

Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson's disease.

The pharmacogenomics journal - 1 Jan 2018

Rieck M, Schumacher-Schuh A F, Altmann V, Callegari-Jacques S M, Rieder C R M, Hutz M H

Abstract excerpt

Levodopa is the most used drug to treat motor symptoms in Parkinson's disease (PD). However, dopaminergic side effects such as nausea and vomiting may occur. Several evidences indicate a major role for dopamine receptors D2 (DRD2) and D3 (DRD3) in emetic activity. The aim of this study was to investigate the relationship of DRD2 rs1799732 and DRD3 rs6280 gene polymorphisms with gastrointestinal (GI) symptoms...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 27779245
DOI: 10.1038/tpj.2016.79

Genes

DRD2
DRD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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