Article
The genomic landscape of CYP2D6 variation in the Indian population.
Pharmacogenomics - 1 Feb 2024
Sivadas Ambily, Rathore Surabhi, Sahana S, Jolly Bani, Bhoyar Rahul C, Jain Abhinav, Sharma Disha, Imran Mohamed, Senthilvel Vigneshwar, Divakar Mohit Kumar, Mishra Anushree, Sivasubbu Sridhar, Scaria Vinod
Abstract excerpt
Aim: The CYP2D6 gene is highly polymorphic, causing large interindividual variability in the metabolism of several clinically important drugs. Materials & methods: The authors investigated the diversity and distribution of CYP2D6 alleles in Indians using whole genome sequences (N = 1518). Functional consequences were assessed using pathogenicity scores and molecular dynamics simulations. Results: The analysis...
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