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Article

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity.

Experimental & molecular medicine - 1 Mar 2024

Yoon Jihoon G, Jang Dong Geon, Cho Sung-Gyu, Lee Chaeyoung, Noh Shin Hye, Seo Soo Kyung, Yu Jung Woo, Chung Hyeon Woo, Han KyeoRe, Kwon Soon Sung, Han Dai Hoon, Oh Jaeseong, Jang In-Jin, Kim Sang-Hoon, Jee Young-Koo, Lee Hyun, Park Dong Won, Sohn Jang Won, Yoon Ho Joo, Kim Chul Hoon, Lee Jae Myun, Kim Sang-Heon, Lee Min Goo

Abstract excerpt

Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase the susceptibility of individuals to AT-DILI and to examine genetic interactions that may lead to isoniazid (INH)-induced hepatotoxicity. We performed a targeted sequencing analysis of 380...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 38424191
DOI: 10.1038/s12276-024-01172-8
PMCID: PMC10984958

Genes

NAT2
ATP7B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity.PMID 38424191Read ↗

The role of NAT2 genetic variants in anti-tuberculosis drug-induced liver injury (AT-DILI): a meta-analysis.Semantic proximity Read ↗

Efficacy, safety, and pharmacokinetics of isoniazid affected by NAT2 polymorphisms in patients with tuberculosis: A systematic review.Semantic proximity Read ↗

Pharmacogenetic association between NAT2 gene polymorphisms and isoniazid induced hepatotoxicity: trial sequence meta-analysis as evidenceSemantic proximity Read ↗

Pharmacogenomic insights into tuberculosis treatment shows the NAT2 genetic variants linked to hepatotoxicity risk: a systematic review and meta-analysis.Semantic proximity Read ↗

NAT2 ultra-slow acetylator and risk of anti-tuberculosis drug-induced liver injury: a genotype-based meta-analysis.Semantic proximity Read ↗

The association between the NAT2 genetic polymorphisms and risk of DILI during anti-TB treatment: a systematic review and meta-analysis.Semantic proximity Read ↗

Pharmacogenomics and mutation informatics: correlation of NAT2 mutations and isoniazid acetylation rate.Semantic proximity Read ↗

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NAT2 variants are associated with drug-induced liver injury caused by anti-tuberculosis drugs in Indonesian patients with tuberculosis.Semantic proximity Read ↗

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