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Article

NAT2 ultra-slow acetylator and risk of anti-tuberculosis drug-induced liver injury: a genotype-based meta-analysis.

Pharmacogenetics and genomics - 1 Jul 2018

Suvichapanich Supharat, Fukunaga Koya, Zahroh Hilyatuz, Mushiroda Taisei, Mahasirimongkol Surakameth, Toyo-Oka Licht, Chaikledkaew Usa, Jittikoon Jiraphun, Yuliwulandari Rika, Yanai Hideki, Wattanapokayakit Sukanya, Tokunaga Katsushi

Abstract excerpt

BACKGROUND: NAT2 slow acetylator is a confirmed risk of anti-tuberculosis drug-induced liver injury (ATDILI). However, NAT2 ultra-slow acetylators, a new refinement among NAT2 slow acetylators, have been recently proposed. The patients with NAT2 genotypes of *6A/*6A, *6A/*7B and *7B/*7B are referred to in this group. OBJECTIVE: We aim to prove an association of the NAT2 ultra-slow acetylators with the risk of...

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Share to Acetylation
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Chemical and Drug Induced Liver Injury

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 29781872
DOI: 10.1097/FPC.0000000000000339

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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