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Article

Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens.

Clinical pharmacology and therapeutics - 1 Apr 2021

Nicoletti Paola, Devarbhavi Harshad, Goel Ashish, Venkatesan Radha, Eapen Chundamannil E, Grove Jane I, Zafer Samreen, Bjornsson Einar, Lucena M Isabel, Andrade Raul J, Pirmohamed Munir, Wadelius Mia, Larrey Dominique, Maitland-van der Zee Anke-Hilse, Ibanez Luisa, Watkins Paul B, Daly Ann K, Aithal Guruprasad P

Abstract excerpt

Drug-induced liver injury (DILI) is a complication of treatment with antituberculosis (TB) drugs, especially in isoniazid (INH)-containing regimens. To investigate genetic risk factors, we performed a genomewide association study (GWAS) involving anti-TB DILI cases (55 Indian and 70 European) and controls (1,199 Indian and 10,397 European). Most cases were treated with a standard anti-TB drug regimen; all...

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Identifiers

PMID: 33135175
DOI: 10.1002/cpt.2100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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