Compartment-specific mutational landscape of clonal hematopoiesis.

doi:10.1038/s41375-022-01700-3

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Article

Compartment-specific mutational landscape of clonal hematopoiesis.

Leukemia - 1 Nov 2022

Hartmann Luise, Hecker Judith S, Rothenberg-Thurley Maja, Rivière Jennifer, Jentzsch Madlen, Ksienzyk Bianka, Buck Michèle C, van der Garde Mark, Fischer Luise, Winter Susann, Rauner Martina, Tsourdi Elena, Weidner Heike, Sockel Katja, Schneider Marie, Kubasch Anne S, Nolde Martin, Hausmann Dominikus, Lützner Jörg, Goralski Szymon, Bassermann Florian, Spiekermann Karsten, Hofbauer Lorenz C, Schwind Sebastian, Platzbecker Uwe, Götze Katharina S, Metzeler Klaus H

Abstract excerpt

Clonal hematopoiesis (CH) is characterized by somatic mutations in blood cells of individuals without hematologic disease. While the mutational landscape of CH in peripheral blood (PB) has been well characterized, detailed analyses addressing its spatial and cellular distribution in the bone marrow (BM) compartment are sparse. We studied CH driver mutations in healthy individuals (n = 261) across different...

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Identifiers

PMID: 36131041
DOI: 10.1038/s41375-022-01700-3
PMCID: PMC9613457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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