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Article

Levofloxacin-induced MexS mutation triggers imipenem-relebactam resistance in a KPC-producing Pseudomonas aeruginosa.

International journal of antimicrobial agents - 1 May 2024

Wang Leilei, Zhou Xun, Lu Yanyan, Zhang Xuefei, Jiang Jianping, Sun Zhewei, Yin Mengyun, Doi Yohei, Wang Minggui, Guo Qinglan, Yang Fan

Abstract excerpt

OBJECTIVES: Imipenem-relebactam (IMR), a novel β-lactam/β-lactamase inhibitor combination, is recommended for infections caused by difficult-to-treat Pseudomonas aeruginosa. This study aimed to investigate the evolution trajectory of IMR resistance under the selection of levofloxacin in P. aeruginosa. METHODS: Antimicrobial susceptibility testing, complete genome sequencing and gene manipulation experiments were...

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Identifiers

PMID: 38417706
DOI: 10.1016/j.ijantimicag.2024.107119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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