Article
The structure of psychiatric comorbidity without selection and assortative mating.
Translational psychiatry - 26 Feb 2024
Ayorech Ziada, Torvik Fartein Ask, Cheesman Rosa, Eilertsen Espen M, Valstad Mathias, Bjørndal Ludvig Daae, Røysamb Espen, Havdahl Alexandra, Ystrøm Eivind
Abstract excerpt
The widespread comorbidity observed across psychiatric disorders may be the result of processes such as assortative mating, gene-environment correlation, or selection into population studies. Between-family analyses of comorbidity are subject to these sources of bias, whereas within-family analyses are not. Because of Mendelian inheritance, alleles are randomly assigned within families, conditional on parental...
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