Article
The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates.
Malaria journal - 12 Mar 2018
Gendrot Mathieu, Foguim Francis Tsombeng, Robert Marie Gladys, Amalvict Rémy, Mosnier Joel, Benoit Nicolas, Madamet Marylin, Pradines Bruno
Abstract excerpt
BACKGROUND: Plasmodium falciparum resistance to artemisinin-based combination therapy has emerged and spread in Southeast Asia. In areas where artemisinin resistance is emerging, the efficacy of combination is now based on partner drugs. In this context, the identification of novel markers of resistance is essential to monitor the emergence and spread of resistance to these partner drugs. The ubiquitylation...
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