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Article

Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study.

Journal of atherosclerosis and thrombosis - 1 Jul 2024

Kujala Iida, Vangipurapu Jagadish, Maaniitty Teemu, Saraste Antti, Kere Juha, Knuuti Juhani

Abstract excerpt

AIM: Clinical risk scores for coronary artery disease (CAD) are used in clinical practice to select patients for diagnostic testing and therapy. Several studies have proposed that polygenic risk scores (PRSs) can improve the prediction of CAD, but the scores need to be validated in clinical populations with accurately characterized phenotypes. We assessed the predictive power of the three most promising PRSs for...

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Identifiers

PMID: 38403640
DOI: 10.5551/jat.64623
PMCID: PMC11224689

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