Article
Concordance in Oncogenic Alterations Between the Primary Tumor and Advanced Disease: Insights Into the Heterogeneity of Intrahepatic Cholangiocarcinoma.
JCO precision oncology - 1 Feb 2024
McIntyre Sarah M, Preston William A, Walch Henry, Sharib Jeremy, Kundra Ritika, Sigel Carlie, Lidsky Michael E, Allen Peter J, Morse Michael A, Chen Wei, Cercek Andrea, Harding James J, Abou-Alfa Ghassan K, O'Reilly Eileen M, Park Wungki, Balachandran Vinod P, Drebin Jeffrey, Soares Kevin C, Wei Alice, Kingham T Peter, D'Angelica Michael I, Iacobuzio-Donahue Christine, Jarnagin William R
Abstract excerpt
PURPOSE: Intrahepatic cholangiocarcinoma (ICCA) is characterized by significant phenotypic and clinical heterogeneities and poor response to systemic therapy, potentially related to underlying heterogeneity in oncogenic alterations. We aimed to characterize the genomic heterogeneity between primary tumors and advanced disease in patients with ICCA. METHODS: Biopsy-proven CCA specimens (primary tumor and paired...
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