Article
Pharmacogenetic study on risperidone long-acting injection: influence of cytochrome P450 2D6 and pregnane X receptor on risperidone exposure and drug-induced side-effects.
Journal of clinical psychopharmacology - 1 Jun 2013
Choong Eva, Polari Andrea, Kamdem Rigobert Hervais, Gervasoni Nicola, Spisla Caesar, Jaquenoud Sirot Eveline, Bickel Graziella Giacometti, Bondolfi Guido, Conus Philippe, Eap Chin B
Abstract excerpt
Risperidone is metabolized by polymorphic enzymes, and a large variability in plasma concentration and therapeutic response is observed. Risperidone long-acting injection (RLAI) avoids the first-pass effect, and little is known about the influence of gene polymorphisms involved in its pharmacokinetics. The influence on plasma concentrations of risperidone (RIS), its metabolite 9-hydroxy-risperidone, and on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.