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Transcription factors of the Nuclear Factor I (NFI) family control hepatocyte differentiation and cytochrome P450 activity in human liver

15 Oct 2025

Abstract excerpt

Interindividual variability in hepatic drug metabolism and transport is well-known, and genetic variation in pharmacogenes impacts the efficacy and safety of drug treatments. Recent reports have indicated that the minor allele of the nuclear transcription factor I/B (NFIB), rs28379954 T>C, affects the metabolism of risperidone and clozapine, which are mediated by CYP2D6 and CYP1A2, respectively. First, we...

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PMID: 41106572
DOI: 10.1016/j.phrs.2025.107998

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