Article
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
Clinical pharmacology and therapeutics - 1 May 2022
Lenk Hasan Çağın, Klöditz Katharina, Johansson Inger, Smith Robert Løvsletten, Jukić Marin M, Molden Espen, Ingelman-Sundberg Magnus
Abstract excerpt
The genetic background for interindividual variability of the polymorphic CYP2D6 enzyme activity remains incompletely understood and the role of NFIB genetic polymorphism for this variability was evaluated in this translational study. We investigated the effect of NFIB expression in vitro using 3D liver spheroids, Huh7 cells, and the influence of the NFIB polymorphism on metabolism of risperidone in patients in...
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