Article
Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish
14 Mar 2017
Abstract excerpt
ABSTRACT Pluripotent stem cell (PSC)-derived organoids are miniature, three-dimensional human tissues generated by the application of developmental biological principles to PSCs in vitro. The approach to generate organoids uses a combination of directed differentiation, morphogenetic processes, and the intrinsically driven self-assembly of cells that mimics organogenesis in the developing embryo. The resulting...