Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring JC Polyomavirus Sequences and Human Gene Expression in Brain Tissue of Patients With Progressive Multifocal Leukoencephalopathy

14 Feb 2024

Abstract excerpt

Progressive multifocal leukoencephalopathy (PML) is a rare neurological condition associated with reactivation of dormant JC polyomavirus (JCPyV). In this study, we characterized gene expression and JCPyV rearrangements in PML brain tissue. Infection of white matter astrocytes and oligodendrocytes as well as occasional brain cortex neurons was shown. PML brain harbored exclusively rearranged JCPyV variants. Viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Full-Duplex Wireless Communications
Share to Plant Virus Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38365889
DOI: 10.1093/infdis/jiae066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring JC Polyomavirus Sequences and Human Gene Expression in Brain Tissue of Patients With Progressive Multifocal LeukoencephalopathyPMID 38365889Read ↗

JC polyomavirus: a short review of its biology, its association with progressive multifocal leukoencephalopathy, and the diagnostic value of different methods to manifest its activity or presence.Semantic proximity Read ↗

Progressive Multifocal Leukoencephalopathy: Molecular Biology, Pathogenesis and Clinical ImpactSemantic proximity Read ↗

The human JC polyomavirus (JCPyV): virological background and clinical implications.Semantic proximity Read ↗

Traffic of JC Virus from Sites of Initial Infection to the Brain: The Path to Progressive Multifocal LeukoencephalopathySemantic proximity Read ↗

JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.Semantic proximity Read ↗

Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain DiseaseSemantic proximity Read ↗

Differentiation of highly pathogenic strains of human JC polyomavirus in neurological patients by next generation sequencing.Semantic proximity Read ↗

Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication RateSemantic proximity Read ↗

Viral variant nucleotide sequences help expose leukocytic positioning in the JC virus pathway to the CNS.Semantic proximity Read ↗

Presence and expression of JCV early gene large T Antigen in the brains of immunocompromised and immunocompetent individualsSemantic proximity Read ↗

Single-Molecule Sequencing Revealing the Presence of Distinct JC Polyomavirus Populations in Patients With Progressive Multifocal Leukoencephalopathy.Semantic proximity Read ↗

Pathogenesis of Progressive Multifocal Leukoencephalopathy—RevisitedSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.