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Article

Single-Molecule Sequencing Revealing the Presence of Distinct JC Polyomavirus Populations in Patients With Progressive Multifocal Leukoencephalopathy.

The Journal of infectious diseases - 15 Mar 2017

Seppälä Hanna, Virtanen Elina, Saarela Mika, Laine Pia, Paulín Lars, Mannonen Laura, Auvinen Petri, Auvinen Eeva

Abstract excerpt

Background: Progressive multifocal leukoencephalopathy (PML) is a fatal disease caused by reactivation of JC polyomavirus (JCPyV) in immunosuppressed individuals and lytic infection by neurotropic JCPyV in glial cells. The exact content of neurotropic mutations within individual JCPyV strains has not been studied to our knowledge. Methods: We exploited the capacity of single-molecule real-time sequencing...

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Identifiers

PMID: 28453853
DOI: 10.1093/infdis/jiw399

Genes

PML

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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