Article
JC Polyomavirus Abundance and Distribution in Progressive Multifocal Leukoencephalopathy (PML) Brain Tissue Implicates Myelin Sheath in Intracerebral Dissemination of Infection.
PloS one - 1 Jan 2016
Wharton Keith A, Quigley Catherine, Themeles Marian, Dunstan Robert W, Doyle Kathryn, Cahir-McFarland Ellen, Wei Jing, Buko Alex, Reid Carl E, Sun Chao, Carmillo Paul, Sur Gargi, Carulli John P, Mansfield Keith G, Westmoreland Susan V, Staugaitis Susan M, Fox Robert J, Meier Werner, Goelz Susan E
Abstract excerpt
Over half of adults are seropositive for JC polyomavirus (JCV), but rare individuals develop progressive multifocal leukoencephalopathy (PML), a demyelinating JCV infection of the central nervous system. Previously, PML was primarily seen in immunosuppressed patients with AIDS or certain cancers, but it has recently emerged as a drug safety issue through its association with diverse immunomodulatory therapies. To...
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