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Article

Differentiation of highly pathogenic strains of human JC polyomavirus in neurological patients by next generation sequencing.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Apr 2024

Auvinen Eeva, Honkimaa Anni, Laine Pia, Passerini Sara, Moens Ugo, Pietropaolo Valeria, Saarela Mika, Maunula Leena, Mannonen Laura, Tynninen Olli, Haapasalo Hannu, Rauramaa Tuomas, Auvinen Petri, Liimatainen Hanna

Abstract excerpt

BACKGROUND: JC polyomavirus (JCPyV) persists asymptomatic in more than half of the human population. Immunocompromising conditions may cause reactivation and acquisition of neurotropic rearrangements in the viral genome, especially in the non-coding control region (NCCR). Such rearranged JCPyV strains are strongly associated with the development of progressive multifocal leukoencephalopathy (PML). METHODS: Using...

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PMID: 38364704
DOI: 10.1016/j.jcv.2024.105652

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