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Presence and expression of JCV early gene large T Antigen in the brains of immunocompromised and immunocompetent individuals

21 Oct 2008

Abstract excerpt

JC virus (JCV) is a polyomavirus that asymptomatically infects up to 80% of the worldwide human population and establishes latency in the kidney. In the case of host immunodeficiency, it can cause progressive multifocal leukoencephalopathy (PML), which is a fatal demyelinating disease of the central nervous system. In an attempt to understand better PML pathogenesis and JCV infection, the presence of the JCV...

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PMID: 19040292
DOI: 10.1002/jmv.21313

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