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Progressive Multifocal Leukoencephalopathy: Molecular Biology, Pathogenesis and Clinical Impact

1 Jan 1997

Abstract excerpt

The human polyomaviruses JC virus (JCV) and BK virus (BKV) have long been known as onco- and neurooncogenic. Interest in their oncogenic potential has reemerged with the discovery of simian virus 40 DNA in human brain tumors including the pituitary as well as in bone tumors and mesotheliomas. The only human disease caused by an infection with the human polyomavirus JCV is progressive multifocal...

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PMID: 9450227
DOI: 10.1159/000150537

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