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Article

Viral variant nucleotide sequences help expose leukocytic positioning in the JC virus pathway to the CNS.

Journal of leukocyte biology - 1 Apr 1999

Jensen P N, Major E O

Abstract excerpt

The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worldwide with approximately 80% of adults testing positive for JCV antibodies. In addition to the...

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Source

Identifiers

PMID: 10204570
DOI: 10.1002/jlb.65.4.428

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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