Article
FUS-induced neurotoxicity is prevented by inhibiting GSK-3β in a Drosophila model of amyotrophic lateral sclerosis.
Human molecular genetics - 21 Mar 2022
Choi Hyun-Jun, Lee Ji Young, Cha Sun Joo, Han Yeo Jeong, Yoon Ja Hoon, Kim Hyung-Jun, Kim Kiyoung
Abstract excerpt
Amyotrophic lateral sclerosis (ALS)-linked mutations in fused in sarcoma (FUS) lead to the formation of cytoplasmic aggregates in neurons. They are believed to play a critical role in the pathogenesis of FUS-associated ALS. Therefore, the clearance and degradation of cytoplasmic FUS aggregates in neurons may be considered a therapeutic strategy for ALS. However, the molecular pathogenic mechanisms behind...
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