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Article

PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.

Human molecular genetics - 1 Dec 2016

Chen Yanbo, Deng Jianwen, Wang Peng, Yang Mengxue, Chen Xiaoping, Zhu Li, Liu Jianghong, Lu Bingwei, Shen Yan, Fushimi Kazuo, Xu Qi, Wu Jane Y

Abstract excerpt

Dysregulation of Fused in Sarcoma (FUS) gene expression is associated with fronto-temporal lobar degeneration (FTLD), and missense mutations in the FUS gene have been identified in patients affected by amyotrophic lateral sclerosis (ALS). However, molecular and cellular defects underlying FUS proteinopathy remain to be elucidated. Here, we examined whether genes important for mitochondrial quality control play a...

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Source

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Identifiers

PMID: 27794540
DOI: 10.1093/hmg/ddw310
PMCID: PMC6078632

Genes

FUS
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.PMID 27794540Read ↗

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